An additional 8 steps brought them for their focus on. Each phase within a synthesis inevitably produces some facet merchandise, so not all of the starting off product ends up as conolidine. But 18% of it does--a respectable proportion for an advanced synthesis.
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The first asymmetric total synthesis of conolidine was produced by Micalizio and coworkers in 2011.[2] This synthetic route will allow usage of both enantiomer (mirror picture) of conolidine through an early enzymatic resolution.
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Scientists feel that b